Piezoelectric stimulation by ultrasound facilitates chondrogenesis of mesenchymal stem cells
نویسندگان
چکیده
منابع مشابه
Nanoscale Mechanical Stimulation of Human Mesenchymal Stem Cells
Introduction: Mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. These include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. In this research we wer...
متن کاملElectrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem cells (MSCs) have high therapeutic potential for cartilage regeneration, we investigated the actions of ES during ...
متن کاملPreconditioning of Rabbit Mesenchymal Stem Cells with Low Intensity Ultrasound to Induce Chondrogenesis in Vivo
INTRODUCTION For tissue regeneration, in vivo implantation of undifferentiated multipotent MSCs may pose a high risk of unforeseen events, such as heterotopic tissue formation. Therefore, regulatory signals of in vitro differentiation of MSCs are of importance and have been extensively studied for the induction of proper lineage commitment. In order to use MSCs to repair articular cartilage, it...
متن کاملDynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
The objective of this study was to investigate the influence of dynamic compressive loading on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-beta3. Isolated porcine MSCs were suspended in 2% agarose and subjected to intermittent dynamic compression (10% strain) for a period of 42 days in a dynamic compression bioreactor. After 42 days in culture, the free-swelling speci...
متن کاملSpecific microRNA expression during chondrogenesis of human mesenchymal stem cells.
Mesenchymal stem cells (MSCs) have the capacity to self-renew and differentiate into multiple cell types, but little is known about the precise mechanism of this procedure. Recent studies show that a group of short noncoding RNAs called microRNAs (miRNAs) play a key role in this procedure. However, little work has been done to determine the miRNAs which specifically regulate the differentiation...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of the Acoustical Society of America
سال: 2020
ISSN: 0001-4966
DOI: 10.1121/10.0001590